Training Faculty for Cancer Biology (CAB)

Program Directors: James J. Manfredi, Ph.D., Matthew O'Connell, Ph.D.
Steering Committee: Stuart Aaronson, M.D., Liliana Ossowski, Ph.D., Robert Krauss, Ph.D., Ihor Lemischka, Ph.D., Aneel Aggarwal, Ph.D.
Advisory Committee on Clinical Cancer: Dana H. Bovbjerg, Ph.D., Steven Itzkowitz, M.D., David Burstein, M.D., Simon Hall, M.D.

Training Faculty

• Stuart A. Aaronson, M.D., Professor and Chair, Department of Oncological Sciences
  Type(s) of Research: Basic Science Research; Clinical Research
  Research: Molecular genetics of cancers
  
• Aneel Aggarwal, Ph.D., Professor, Department of Structural and Chemical Biology
  Type(s) of Research: Basic Science Research
  Research: X-ray crystallography studies of DNA/RNA binding proteins
  
• Margaret H. Baron, M.D., Ph.D., Professor, Department of Medicine (Hematology and Medical Oncology)
  Type(s) of Research: Basic Science Research; Translational Research
  Research: Induction and specification of mesoderm and endoderm in the embryo; development of the mammalian blood and vascular systems; stem cell biology; signaling between erythroid cells and other cell types within different developmental niches; enucleation of red blood cells; disorders of red blood cell development; transcriptional regulation of development and differentiation
  
• Emily Bernstein, Ph.D., Assistant Professor, Department of Oncological Sciences
  Type(s) of Research: Basic Science Research; Translational Research
  Research: Our focus is on epigenetic regulation of gene expression in multiple biological pathways including cancer and stem cell biology. This includes mechanisms that alter the chromatin template such as: histone modifications, histone variants, and non-coding RNAs.
  
• James J. Bieker, Ph.D., Professor, Department of Developmental and Regenerative Biology
  Type(s) of Research: Basic Science Research
  Research: Transcriptional regulation of red cell specific gene expression
  
• David E. Burstein, M.D., Associate Professor, Department of Pathology
  Type(s) of Research: Basic Science Research
  Research: Markers of tumor stem cells and tumor cell signal transduction
  
• Ross Cagan, Ph.D., Professor, Department of Developmental and Regenerative Biology
  Type(s) of Research: Basic Science Research; Clinical Research
  Research: Drosophila disease and development models, cancer models including breast, lung, and thyroid, diabetes models including heart dysfunction, epithelial development including retinal patterning
  
• Arthur I. Cederbaum, Ph.D., Professor, Department of Pharmacology and Systems Therapeutics
  Type(s) of Research: Basic Science Research
  Research: Cytochrome P450 biochemistry and role of oxidative stress in alcohol-induced liver injury
  
• Andrew M.L. Chan, Ph.D., Associate Professor, Department of Oncological Sciences
  Type(s) of Research: Basic Science Research
  Research: Molecular carcinogenesis and signal transduction
  
• Shu-Hsia Chen, Ph.D., Associate Professor, Department of Gene and Cell Medicine
  Type(s) of Research: Basic Science Research
  Research: Cancer Immunology, immune modulated cancer therapy
  
• Evan L. Flatow, M.D., Professor and Chair, Department of Orthopaedics
  Type(s) of Research: Basic Science Research
  Research: Markers of tumor stem cells and tumor cell signal transduction
  
• Scott L. Friedman, M.D., Professor, Department of Medicine
  Type(s) of Research: Basic Science Research; Clinical Research
  Research: Role of KLF6 tumor suppressor gene in cancer pathogenesis; molecular regulation of hepatic fibrosis; Testing of novel antifibrotic therapies in preclinical models and human trials
  
• Doris Germain, Ph.D., Associate Professor, Department of Medicine (Hematology and Medical Oncology)
  Type(s) of Research: Basic Science Research; Translational Research
  Research: Role of cyclins in prognosis of breast cancer; pregnancy-associated breast cancer; role of estrogen receptor in the mitochondria.
  
• Simon Hall, M.D., Associate Professor, Department of Urology
  Type(s) of Research: Basic Science Research; Clinical Research
  Research: Gene therapy for prostate cancer
  
• Ravi Iyengar, Ph.D., Professor and Chair, Department of Pharmacology and Systems Therapeutics
  Type(s) of Research: Basic Science Research
  Research: Cellular signaling systems with emphasis on heterotrimeric G proteins
  
• Robert S. Krauss, Ph.D., Professor, Department of Developmental and Regenerative Biology
  Type(s) of Research: Basic Science Research
  Research: Cell Adhesion and Signal Transduction in Pattern Formation and Cell Differentiation During Development
  
• Sergio A. Lira, M.D., Ph.D., Professor, Department of Medicine
  Type(s) of Research: Basic Science Research
  Research: Chemokines; leukocyte trafficking; angiogenesis; lymphoid development; mouse genetics
  
• James J. Manfredi, Ph.D., Associate Professor, Department of Oncological Sciences
  Type(s) of Research: Basic Science Research
  Research: Molecular basis of p53 tumor suppressor activity
  
• John A. Martignetti, M.D., Ph.D., Associate Professor, Department of Genetics and Genomic Sciences
  Type(s) of Research: Basic Science Research
  Research: Genomics, molecular biology, cancer genetics, gene discovery, hereditary cancers, cancer syndromes, tumor suppressor genes, linkage analysis
  
• Marek Mlodzik, Ph.D., Professor, Department of Developmental and Regenerative Biology
  Type(s) of Research: Basic Science Research
  Research: Cell-cell interactions during epithelial and nervous system patterning: planar polarity establishment
  
• Goutham Narla, M.D., Ph.D., Assistant Professor, Department of Medicine
  Type(s) of Research: Basic Science Research; Translational Research
  Research: Role of tumor suppressor and oncogenes in tumorigenesis and metastasis; genetics of chemotherapy resistance
  
• Matthew J. O'Connell, Ph.D., Associate Professor, Department of Oncological Sciences
  Type(s) of Research: Basic Science Research
  Research: Regulation of the cell cycle; control over genomic stability and chromosome dynamics; the design of novel strategies for anti-cancer therapies
  
• Roman Osman, Ph.D., Professor, Department of Structural and Chemical Biology
  Type(s) of Research: Basic Science Research
  Research: Molecular theoretical biophysics of enzymatic DNA repair; alosterism and cooperativity in the blood coagulation pathway; molecular mechanism of autoimmune diseases; protein folding
  
• Liliana Ossowski, Ph.D., Professor, Department of Medicine
  Type(s) of Research: Basic Science Research
  Research: Proteases in cancer metastasis, tumor dormancy, receptors, integrins
  
• Zhen-Qiang Pan, Ph.D., Professor, Department of Oncological Sciences
  Type(s) of Research: Basic Science Research
  Research: Ubiquitin signaling in cancer biology
  
• Cathie Pfleger, Ph.D., Assistant Professor, Department of Oncological Sciences
  Type(s) of Research: Basic Science Research
  Research: How the processes of growth and proliferation are regulated and how loss of that regulation leads to cancer, with a special emphasis on regulation by the ubiquitin pathway.
  
• Kirsten Sadler-Edepli, Ph.D., Assistant Professor, Department of Developmental and Regenerative Biology
  Type(s) of Research: Basic Science Research
  Research: Using zebrafish to understand liver development, regeneration and disease
  
• Edward H. Schuchman, Ph.D., Professor, Department of Genetics and Genomic Sciences
  Type(s) of Research: Basic Science Research; Translational Research
  Research: The biology and treatment of lysosomal storage disorders; the role of lipid hydrolases in cell signaling
  
• Mihaela Skobe, Ph.D., Assistant Professor, Department of Oncological Sciences
  Type(s) of Research: Basic Science Research
  Research: Cancer metastasis, lymphangiogenesis, angiogenesis
  
• Hans-Willem Snoeck, M.D., Ph.D., Associate Professor, Department of Gene and Cell Medicine
  Research: Stem cell biology; immunology; gene therapy; hematopoiesis
  
• Sergei Y. Sokol, Ph.D., Professor, Department of Developmental and Regenerative Biology
  Type(s) of Research: Basic Science Research
  Research: Cell polarity in vertebrate development, neural development, axis specification, Wnt signaling, morphogenetic movements, asymmetric cell division.
  
• David W. Sternberg, M.D., Ph.D., Assistant Professor, Department of Medicine (Hematology and Medical Oncology)
  Type(s) of Research: Basic Science Research
  Research: Aberrant protein tyrosine kinase signaling in cancer; translational control of gene expression in malignancy; mechanisms of resistance to protein tyrosine kinase inhibitors
  
• Rong Wang, Ph.D., Associate Professor, Department of Genetics and Genomic Sciences
  Type(s) of Research: Basic Science Research
  Research: Proteomics and biological mass spectrometry
  
• Lu-Hai Wang, Ph.D., Professor, Department of Microbiology
  Type(s) of Research: Basic Science Research
  Research: Oncogenes; cell transformation and signal transduction of receptor tyrosine kinases; molecular basis for oncogenesis and targets for cancer therapy
  
• Paul M. Wassarman, Ph.D., Professor , Department of Developmental and Regenerative Biology
  Type(s) of Research: Basic Science Research
  Research: Mechanisms of fertilization in mammals
  
• Savio L. C. Woo, Ph.D., Professor, Department of Gene and Cell Medicine
  Type(s) of Research: Basic Science Research; Clinical Research
  Research: Gene Therapy for Cancer and Inherited Diseases
  
• Qin Yu, Ph.D., Assistant Professor , Department of Oncological Sciences
  Type(s) of Research: Basic Science Research
  Research: Effects of tumor microenvironment on tumor invasion/metastasis and tumor angiogenesis; Identification of targets and agents for therapeutic intervention of human glioma, ovarian cancer, melanoma, and breast cancer.
  
• David Y. Zhang, M.D., Ph.D., Associate Professor, Department of Pathology
  Type(s) of Research: Clinical Research; Translational Research
  Research: Molecular cancer biology with focus on signal transduction pathways and technology development for cancer diagnosis
  
• Ming-Ming Zhou, Ph.D., Professor and Chair, Department of Structural and Chemical Biology
  Type(s) of Research: Basic Science Research
  Research: Structural biology of receptor signaling, histone-directed chromatin biology and gene regulation; Mechanism-based disease biology and drug discovery; Protein NMR spectroscopy, biochemistry, molecular and chemical biology