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Stuart A. Aaronson, M.D., Professor and Chair, Department of Oncological Sciences
Molecular genetics of cancers
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Aging, Cancer, Growth Factors and Receptors, Oncogenes, Signal Transduction
Clinical Research Topic(s):
Patient-oriented research, Translational research
Aneel Aggarwal, Ph.D., Professor, Department of Structural and Chemical Biology
X-ray crystallography studies of DNA/RNA binding proteins
Training Area(s):
Type(s) of Research:
Research Topic(s):
DNA Repair, DNA Replication, Structural Biology, Transcription Factors, Translation
Fadi G. Akar, Ph.D., Assistant Professor, Cardiovascular Institute and Center for Cardiovascular Health
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Cardiovascular, Electrophysiology, Gap Junctions, Mathematical and Computational Biology
Cristina M. Alberini, Ph.D., Associate Professor, Department of Neuroscience
Molecular mechanisms of long-term memory
Training Area(s):
Type(s) of Research:
Research Topic(s):
Addiction, Brain, cAMP, Gene Expressions, Memory, Neurobiology, Protein Translation, Synapses, Synaptic Plasticity, Transcription Factors
Konstantina Alexandropoulos, , Senior Faculty, Department of Medicine
Thymic epithelial cell differentiation and regulation of T cell tolerance; mechanisms of T cell-mediated autoimmunity; Molecular and cellular mechanisms that regulate leukocyte trafficking
Training Area(s):
Type(s) of Research:
Research Topic(s):
Autoimmunity, Cell Adhesion, Epithelial Cells, Immunological Tolerance, Signal Transduction
Mark W. Babyatsky, M.D., Associate Professor, Department of Medicine
Mucosal defense in the gastrointestinal tract: somatostatin, intestinal trefoil factor
Training Area(s):
Type(s) of Research:
Research Topic(s):
Inflammation, Knockout Mice, Neuropeptides
Meena Bansal, M.D., Assistant Professor, Department of Medicine (Liver Diseases)
Role of chemokine receptors, CXCR4 and CCR5, on stellate cell biology and fibrogenesis; molecular regulation of hepatic fibrosis and regeneration
Training Area(s):
Type(s) of Research:
Research Topic(s):
AIDS/HIV, Cell Biology, Chemokines, Fibrosis, Hepatitis C Virus, Knockout Mice, Molecular Biology, Regeneration, Transcription Factors, Transcriptional Activation and Repression, Viruses and Virology
Margaret H. Baron, M.D., Ph.D., Professor, Department of Medicine (Hematology and Medical Oncology)
Induction and specification of mesoderm and endoderm in the embryo; development of the mammalian blood and vascular systems; stem cell biology; signaling between erythroid cells and other cell types within different developmental niches; enucleation of red blood cells; disorders of red blood cell development; transcriptional regulation of development and differentiation
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Bioinformatics, Cancer, Cardiovascular, Cellular Differentiation, Cytokines, Developmental Biology, Embryology, Endothelial Cells, Gene Regulation, Gene Therapy, Genetics, Growth Factors and Receptors, Hematopoiesis, Image Analysis, Imaging, Knockout Mice, Microarray, Migration, Morphogenesis, Nucleus, Organogenesis, Protein Complexes, Protein Structure/Function, Regeneration, Signal Transduction, Stem Cells, Transcription Factors, Transcriptional Activation and Repression, Transgenic Mice, Transplantation, Vascular Development
Clinical Research Topic(s):
Translational research
Christopher F. Basler, Ph.D., Assistant Professor, Department of Microbiology
Molecular determinants of virulence of emerging viruses, including Ebola virus, Nipah virus and pandemic influenza virus
Training Area(s):
Type(s) of Research:
Research Topic(s):
Biodefense, Cytokines, Dendritic Cells, Ebola Virus, Infectious Disease, Influenza Virus, Interferon, Interferon Antagonists, Interferon Resistance, Nipah Virus, Viruses and Virology
Mark Baxter, Ph.D., Senior Faculty, Department of Neuroscience
Training Area(s):
Type(s) of Research:
Research Topic(s):
David H. Bechhofer, Ph.D., Professor, Department of Pharmacology and Systems Therapeutics
Prokaryotic mRNA decay and stable RNA processing
Training Area(s):
Type(s) of Research:
Research Topic(s):
Bacterial Genetics, DNA Recombination, Drug Resistance, Enzymology, Gene Regulation, mRNA Decay, Post-Transcriptional Processing, Protein Structure/Function, Protein Translation
Deanna L. Benson, Ph.D., Associate Professor, Department of Neuroscience
" Synapse Formation and Stabilization " Synapse Targeting " Cortical Axon Guidance " Fetal Alcohol Syndrome " Connectivity-Based Brain Disorders
Training Area(s):
Type(s) of Research:
Research Topic(s):
Axon Guidance, Brain, Cell Adhesion, Cell Motility, Cellular Differentiation, Cytoskeleton, Developmental Biology, GABA, Growth, Growth Cone, Imaging, Membranes, Microtubules, Morphogenesis, Neuro-degeneration/protection, Neurotoxicology, Neurotransmitters, Phosphorylation, Protein Trafficking & Sorting, Synapses
Andrew D. Bergemann, Ph.D., Assistant Professor, Department of Pathology
Neural cell fate determination
Training Area(s):
Type(s) of Research:
Research Topic(s):
Anatomy, Auditory, Axon Guidance, Axonal Growth and Degeneration, Blood-Brain Barrier, Bone Biology, Bone Metabolism, Brain, Cancer, Cellular Differentiation, Cerebral Cortex, Chromatin, Cognitive Neuroscience, Developmental Biology, Developmental Neurobiology, DNA Recombination, DNA Repair, DNA Replication, Embryology, Epigenetics, Epilepsy, Gene Expressions, Gene Regulation, Genetics, Growth Cone, Growth Factors and Receptors, Hematopoiesis, Human Genetics and Genetic Disorders, Imaging, Inner Ear, Knockout Mice, Leukemia, Mental Retardation, Morphogenesis, Motor Control, Motor Neuron, Neural Code, Neurotransmitters, Oncogenes, Organogenesis, Protein Trafficking & Sorting, Protein Translation, Receptors, Spinal Cord, Transcriptional Activation and Repression, Tumor Suppressor Genes
M. Cecilia Berin, Ph.D., Assistant Professor, Department of Pediatrics
Gastrointestinal dendritic cells in allergic inflammation; Role of IgE receptors on intestinal epithelial cells in food allergy
Training Area(s):
Type(s) of Research:
Research Topic(s):
Allergy, Antigen Presentation, Cellular Immunity, Chemokines, Cytokines, Dendritic Cells, Endothelial Cells, Inflammation, Mucosal Immunology
Audrey Bernstein, Ph.D., Assistant Professor, Department of Ophthalmology
Our lab is studying the mechanisms that promote regenerative repair over fibrotic wound healing. Specifically we are investigating the regulation of TGFb, extracellular matrix compositon, and proteases in an effort to control the fibrotic response.
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cellular Differentiation, Extracellular Matrix, Integrins, Proteases, Wound Healing
Emily Bernstein, Ph.D., Assistant Professor, Department of Oncological Sciences
Our focus is on epigenetic regulation of gene expression in multiple biological pathways including cancer and stem cell biology. This includes mechanisms that alter the chromatin template such as: histone modifications, histone variants, and non-coding RNAs.
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Cancer, Cell Biology, Cell Cycle, Cellular Differentiation, Chromatin, Developmental Biology, Epigenetics, Gene Expressions, Gene Regulation, Hematopoiesis, Leukemia, Mitosis, Molecular Biology, Nucleus, Protein Kinases, RNA, Stem Cells, Transcription Factors, Tumor Suppressor Genes
James J. Bieker, Ph.D., Professor, Department of Developmental and Regenerative Biology
Transcriptional regulation of red cell specific gene expression
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cellular Differentiation, Chromatin, Developmental Biology, Gene Regulation, Hematopoiesis, Protein Complexes, Protein Structure/Function, Stem Cells, Transcription Factors, Transcriptional Activation and Repression
David F. Bishop, Ph.D., Professor, Department of Genetics and Genomic Sciences
Heme biosynthesis; biochemical and molecular genetics; enzymology, sequencing, genotyping and bioinformatics
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Bioinformatics, DNA Recombination, Enzymology, Evolution, Gene Regulation, Gene Therapy, Genetics, Genomics, Hematopoiesis, Heme Proteins, Human Genetics and Genetic Disorders, Iron Metabolism, Protein Structure/Function, RNA Splicing & Processing, Sequence Alignment, Stem Cells, Transcription Factors, Transgenic Mice, Transporters
Julie Magarian Blander, Ph.D., Assistant Professor, Department of Medicine
Dendritic cell and macrophage biology, host-pathogen interactions, Toll-like receptors and pattern recognition receptor signaling and cell biology, analysis of immune function in vivo and in vitro, phagocytosis and phagosome maturation, antigen presentation, T cell activation and differentiation, tumor immunity, gene expression, retroviral and lentiviral transductions, protein biochemistry, analysis of transgenic and gene targeted mice.
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Antigen Presentation, Apoptosis/Cell Death, Autoimmunity, Cell Biology, Cellular Differentiation, Cellular Immunity, Dendritic Cells, Gene Discovery, Immunological Tolerance, Immunology, Infectious Disease, Knockout Mice, Lymphocytes, Lysosomes/endosome, Macrophage, Microarray, Signal Transduction, T Cells, Tolerance, Transgenic Mice, Vaccine Development
Clinical Research Topic(s):
Translational research
Robert D. Blitzer, Ph.D., Associate Professor, Department of Psychiatry
Synaptic plasticity; regulation of protein synthesis in CNS neurons; analysis of signaling networks
Training Area(s):
Type(s) of Research:
Research Topic(s):
Brain, Electrophysiology, Memory, Protein Translation, RNA Transport & Localization, Signal Transduction, Synapses, Synaptic Plasticity
Erwin P. Bottinger, M.D., Professor, Department of Medicine
TGF-B/Smad signaling networks and transcriptomics/genomics; gene expression; genomics; proteomics; microarray; systems biology; nephrology; hypertension; diabetes mellitus; pathobiology
Training Area(s):
Type(s) of Research:
Research Topic(s):
Apoptosis/Cell Death, Bioinformatics, Cell Biology, Diabetes, Fibrosis, Genomics, Growth Factors and Receptors, Kidney, Knockout Mice, Signal Transduction
Andrea D. Branch, Ph.D., Associate Professor, Department of Medicine
Molecular biology, pathogenesis, and treatment of the hepatitis C virus (HCV); development and application of novel bioinformatics tools for detecting cryptic genes and regulatory elements, with a special emphasis on infectious RNAs
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Antivirals, Bioinformatics, Cancer, Gene Regulation, Hepatitis C Virus, Interferon Resistance, Liver, RNA, Viruses and Virology
Clinical Research Topic(s):
Translational research
Vladimir Brezina, Ph.D., Associate Professor, Department of Neuroscience
Biological control mechanisms
Training Area(s):
Type(s) of Research:
Research Topic(s):
Behavior, Central Pattern Generator, Electrophysiology, Membranes, Motor Control, Motor Neuron, Muscle Cells, Neural Code, Neural Networks, Neuromodulation, Neuromuscular System, Signal Transduction, Synapses, Theoretical Neuroscience
Jonathan S. Bromberg, M.D., Ph.D., Professor, Department of Gene and Cell Medicine
Cellular and molecular transplant immunology with a focus on tolerance and the roles of regulatory T cells, trafficking, and secondary lymphoid organ structure.
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Antigen Presentation, Autoimmunity, Cellular Immunity, Chemokines, Cytokines, Dendritic Cells, Diabetes, Endothelial Cells, Immunological Tolerance, Immunology, T Cells, Trafficking, Translation
Clinical Research Topic(s):
Translational research
Brian Brown, Ph.D., Assistant Professor, Department of Genetics and Genomic Sciences
Immunology; Immunological Tolerance; Infectious Disease; Inflammation; Antigen Presentation; Dendritic Cells; Autoimmunity; Diabetes; Molecular Biology; Gene Discovery; Gene Expressions; Gene Regulation; RNA; RNA Regulation; microRNA
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Antigen Presentation, Autoimmunity, Cell Biology, Cellular Immunity, Dendritic Cells, Diabetes, Gene Discovery, Gene Expressions, Gene Regulation, Gene Therapy, Immunological Tolerance, Immunology, Infectious Disease, Inflammation, Macrophage, Molecular Biology, Retrovirus, RNA, RNA Splicing & Processing, T Cells, Tolerance, Transcriptional Activation and Repression, Transgenic Mice
Monte S. Buchsbaum, M.D., Professor, Department of Psychiatry
Human brain imaging with positron emission tomography, functional magnetic resonance imaging, and diffusion tensor imaging in normal subjects during neuropsychological tasks and in patients with schizophrenia, panic disorder, and other psychiatric illnesses.
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Brain Imaging, Image Analysis, Magnetic Resonance Imaging, Morphometrics, Positron Emission Tomography, Prefrontal Cortex, Schizophrenia, Texture Analysis, Thalamus
Clinical Research Topic(s):
Patient-oriented research, Translational research
Steven Burakoff, M.D., Professor, Department of Oncological Sciences
T cell immunology focusing on T cell activation. Tumor immunology with a focus on model vaccine development. Regulation of CD4 by HIV.
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
T Cells
Clinical Research Topic(s):
Translational research
David E. Burstein, M.D., Associate Professor, Department of Pathology
Markers of tumor stem cells and tumor cell signal transduction
Training Area(s):
Type(s) of Research:
Research Topic(s):
Anti-Tumor Therapy, Apoptosis/Cell Death, Cancer, Signal Transduction
Joseph D. Buxbaum, Ph.D., Professor, Department of Psychiatry
Molecular and cellular basis of Alzheimer's disease, autism, and schizophrenia
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Alzheimer's Disease, Autism, Behavior, Demyelination, Gene Regulation, Genetics, Genomics, Human Genetics and Genetic Disorders, Knockout Mice, Metastasis, Microarray, Molecular Biology, Myelination, Neurobiology, Protein Structure/Function, Schizophrenia, Signal Transduction, Transgenic Mice
Clinical Research Topic(s):
Translational research
Ross Cagan, Ph.D., Professor, Department of Developmental and Regenerative Biology
Drosophila disease and development models, cancer models including breast, lung, and thyroid, diabetes models including heart dysfunction, epithelial development including retinal patterning
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Cancer Genetics, Developmental Biology, Diabetes
Clinical Research Topic(s):
Translational research
Chenleng Cai, Ph.D., Assistant Professor, Department of Developmental and Regenerative Biology
Interested in deciphering the transcriptional signaling cascades controlling the early induction and development of mammalian heart. Uncovering the transcriptional signaling cascades underlying the early induction and development of heart has important implications for cardiac regenerative biology.
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Cardiovascular, Developmental Biology, Embryology, Stem Cells
Oscar A. Candia, M.D., Professor, Department of Ophthalmology
Electrophysiology; ion channels and transporters; membrane transporters
Training Area(s):
Type(s) of Research:
Research Topic(s):
Biophysics, Electrophysiology, Epithelial Cells
Patrizia Casaccia, M.D., Ph.D., Professor, Department of Neuroscience
Training Area(s):
Type(s) of Research:
Research Topic(s):
Arthur I. Cederbaum, Ph.D., Professor, Department of Pharmacology and Systems Therapeutics
Cytochrome P450 biochemistry and role of oxidative stress in alcohol-induced liver injury
Training Area(s):
Type(s) of Research:
Research Topic(s):
Apoptosis/Cell Death, Cytokines, Enzymology, Glutathione, Heme Proteins, Liver, Macrophage, Mitochondria, Oxidative Stress, Protein Degradation
Andrew M.L. Chan, Ph.D., Associate Professor, Department of Oncological Sciences
Molecular carcinogenesis and signal transduction
Training Area(s):
Type(s) of Research:
Research Topic(s):
Angiogenesis, Apoptosis/Cell Death, Behavior, Brain, Cancer, Caveoloe, Cell Adhesion, Cell Cycle, Cell Division, Cell Motility, Cellular Differentiation, Chemotaxis, Cytoskeleton, Growth, Growth Factors and Receptors, Lipid Signaling, Memory, Metastasis, Neural Networks, Neuro-degeneration/protection, Neurotoxicology, Neurotransmitters, Oncogenes, Phosphorylation, Prostate, Protein Kinases, Protein Phosphatases, Signal Transduction
Hengjun Chao, M.D., Assistant Professor, Department of Medicine (Hematology and Medical Oncology)
Gene therapy for hemophilia, Gene therapy for muscular dystrophy, Immune responses following AAV-based hemophilia gene transfer
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Cellular Immunity, Human Genetics and Genetic Disorders, Immunological Tolerance, Immunology, Lymphocytes, Molecular Biology, Muscular Dystrophy, RNA, RNA Splicing & Processing, T Cells
Clinical Research Topic(s):
Translational research
Benjamin K. Chen, M.D.,Ph.D., Assistant Professor, Department of Medicine (Infectious Diseases)
HIV-1, virus-host interactions, assembly, membrane protein interactions, RNA-Gag interactions, functional cloning, mouse model for lentiviral infection
Training Area(s):
Type(s) of Research:
Research Topic(s):
AIDS/HIV, Antivirals, Cell Adhesion, Cell Motility, Cytoskeleton, Image Analysis, Imaging, Infectious Disease, Lymphocytes, Lysosomes/endosome, Macrophage, Molecular Biology, Protein Trafficking & Sorting, Retrovirus, RNA Transport & Localization, Synapses, T Cells, Trafficking, Vaccine Development, Viruses and Virology
Jia Chen, Sc.D., Associate Professor, Department of Community and Preventive Medicine
Molecular and genetic epidemiology; genetic susceptibility and gene-environment interactions in human diseases
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cancer, Cancer Genetics, Epigenetics, Folates, Genetics, Genomics, Molecular Epidemiology
Shu-Hsia Chen, Ph.D., Associate Professor, Department of Gene and Cell Medicine
Cancer Immunology, immune modulated cancer therapy
Training Area(s):
Type(s) of Research:
Research Topic(s):
Antigen Presentation, Anti-Tumor Therapy, Autoimmunity, Cancer, Dendritic Cells, Gene Therapy, Hematopoiesis, Immune Antagonism, Immunological Tolerance, Immunology, Lymphoma, Microarray, Stem Cells, T Cells, Tolerance, Transplantation, Tumorigenesis
Bernard Cohen, M.D., Professor, Department of Neurology
Vestibular control of natural movement in animals and humans, on earth and in space
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Anatomy, Behavior, Biomechanics/Bioengineering, Central Pattern Generator, Cerebellum, Comparative Anatomy, Computational Neuroscience, Computer Simulation, Electrophysiology, Extracellular Unit Recording, Eye Movements, GABA, Inner Ear, Locomotion, Mathematical Modeling of Biomedical Systems, Microgravity, Motor Control, Neural Code, Neural Networks, Neuromuscular System, Neurophysiology, Postural Control, Space Flight, Structural Biology, Theoretical Neuroscience, Vestibular, Vision
Patricia Cortes, Ph.D., Assistant Professor, Department of Medicine
Molecular mechanism and regulation of antigen receptor gene rearrangement
Training Area(s):
Type(s) of Research:
Research Topic(s):
B Cells, Chromatin, DNA Repair, Immune Deficiency, Immunology, Leukemia, Lymphoma, Molecular Biology, T Cells, V(D)J recombination
Elizabeth C. Cropper, Ph.D., Associate Professor, Department of Neuroscience
Neural basis of behavioral plasticity
Training Area(s):
Type(s) of Research:
Research Topic(s):
Aplysia, Behavior, Brain, Electrophysiology, Imaging, Motor Control, Motor Neuron, Neural Networks, Neurobiology, Neuromodulation, Neurophysiology, Neuroscience, Neurotransmitters, Synapses, Synaptic Plasticity, Systems Neuroscience
Charlotte Cunningham-Rundles, M.D., Ph.D., Professor, Department of Medicine
Human immunodeficiency diseases; mechanisms and treatments
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Allergy, Apoptosis/Cell Death, Autoimmunity, B Cells, Biodefense, Cellular Differentiation, Dendritic Cells, Immunology, Mucosal Immunology
Clinical Research Topic(s):
Patient-oriented research, Translational research
Simon Daefler, M.D., Ph.D., Assistant Professor, Department of Medicine (Infectious Diseases)
Cell and system biology of host-pathogen interactions in infections with intracellular bacterial pathogens
Training Area(s):
Type(s) of Research:
Research Topic(s):
Bacterial Genetics, Biodefense, Cell Biology, Infectious Disease, Mathematical and Computational Biology, Theoretical Biology, Trafficking
Christopher C Dascher, Ph.D., Assistant Professor, Department of Medicine
Antigen presentation and infectious diseases
Training Area(s):
Type(s) of Research:
Research Topic(s):
Dendritic Cells, Evolution, Immunology, Infectious Disease, Vaccine Development
Terry F. Davies, M.D., Professor, Department of Medicine
Mechanisms in autoimmune disease with an emphasis on autoimmune thyroid disease
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Autoimmunity, Immunology, Knockout Mice, Receptors, Stem Cells, T Cells, Thyroid
Clinical Research Topic(s):
Translational research
Robert J. Desnick, M.D., Ph.D., Professor, Department of Genetics and Genomic Sciences
Human molecular genetics; genomics; gene therapy
Training Area(s):
Research Topic(s):
Enzymology, Gene Therapy, Genetics, Genomics, Human Genetics and Genetic Disorders, Lysosomal Storage Diseases, Lysosomes/endosome, Protein Complexes, Protein Degradation, Protein Folding, Protein Structure/Function, Proteomics, Stem Cells
Lakshmi A. Devi, Ph.D., Professor, Department of Pharmacology and Systems Therapeutics
G-protein coupled receptor/signal transduction, opiate addiction and drug abuse mechanisms, neuropeptide biosynthesis and processing
Training Area(s):
Type(s) of Research:
Research Topic(s):
Addiction, Enzymology, Hormones, Neural Networks, Neuropeptides, Opioid/Cannabinoid Receptors, Post-Transcriptional Processing, Protein Trafficking & Sorting, Proteomics, Signal Transduction
George A. Diaz, M.D.,Ph.D., Assistant Professor, Department of Genetics and Genomic Sciences
Molecular genetics of inherited metabolic disease and disease gene discovery
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Chemokines, Chemotaxis, Genetics, Genomics, Human Genetics and Genetic Disorders, Immunology, Microtubules, Signal Transduction, Virulence Genes
Clinical Research Topic(s):
Patient-oriented research, Translational research
Yaozhong Ding, Ph.D., Assistant Professor, Department of Surgery
Cytokine signaling and transcriptional regulation of T effector response
Training Area(s):
Type(s) of Research:
Research Topic(s):
Allergy, Autoimmunity, Cellular Immunity, Cytokines, Developmental Biology, Diabetes, Immunological Tolerance, Immunology, Lymphocytes, Signal Transduction, T Cells, Transcription Factors, Transplantation
Maria A. Diverse-Pierluissi, Ph.D., Associate Professor, Department of Pharmacology and Systems Therapeutics
G protein-mediated modulation of neuronal calcium influx
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cardiovascular, Cell Adhesion, Cell Biology, Cytoskeleton, Electrophysiology, GABA, Imaging, Intracellular Transport, Membrane Proteins/Channels, Membranes, Neurobiology, Neuromodulation, Neurotransmitters, Protein Complexes, Protein Kinases, Protein Trafficking & Sorting, Receptors, Signal Transduction, Trafficking
Michelle Ehrlich, M.D., Senior Faculty, Department of Neurology
Training Area(s):
Type(s) of Research:
Research Topic(s):
Gregory A. Elder, M.D., Associate Professor, Department of Psychiatry
Biological basis of age-related neurodegenerative diseases
Training Area(s):
Type(s) of Research:
Research Topic(s):
Aging, Alzheimer's Disease, Brain, Endothelial Cells, Neuro-degeneration/protection, Stem Cells
Matthew Evans, Ph.D., Assistant Professor, Department of Microbiology
Host cell entry focusing on hepatitis C virus and other viruses.
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cell Adhesion, Cell Biology, Gap Junctions, Glycobiology, Hepatitis C Virus, Imaging, Infectious Disease, Intracellular Transport, Liver, Lysosomes/endosome, Membrane Proteins/Channels, Membranes, Protein Complexes, Protein Trafficking & Sorting, Retrovirus, Virulence Genes, Viruses and Virology
Jin Fan, Ph.D., Assistant Professor, Department of Psychiatry
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Autism, Behavior, Brain Imaging, Cognitive Neuroscience, Neural Networks, Neuroscience
Zahi A. Fayad, Ph.D., Professor, Department of Radiology
Using magnetic resonance imaging to study cardiovascular development and degeneration
Training Area(s):
Type(s) of Research:
Research Topic(s):
Atherosclerosis, Cardiovascular, Computed Tomography, Image Analysis, Imaging, Magnetic Resonance Imaging, Nanotechnology
Dan Felsenfeld, Ph.D., Assistant Professor, Department of Developmental and Regenerative Biology
Regulation of adhesion receptor function in axon guidance and cell migration
Training Area(s):
Type(s) of Research:
Research Topic(s):
Axon Guidance, Biophysics, Cancer, Cell Adhesion, Cell Motility, Cytoskeleton, Developmental Neurobiology, Growth Cone, Migration, Spectroscopy
Ana Fernandez-Sesma, Ph.D., Assistant Professor, Department of Microbiology
Mechanisms of evasion of immunity by dengue and influenza viruses; human immunology in viral infections. Generation of recombinant viruses.
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Antivirals, Biodefense, Cellular Immunity, Chemokines, Cytokines, Dendritic Cells, Immune Antagonism, Immunology, Infectious Disease, Influenza Virus, Interferon, Interferon Antagonists, Paramyxovirus, Virulence Genes, Viruses and Virology
Clinical Research Topic(s):
Translational research
Marta Filizola, Ph.D., Assistant Professor, Department of Structural and Chemical Biology
Structure-function correlation in molecular recognition and signal-transduction through the development and application of computational methods
Training Area(s):
Type(s) of Research:
Research Topic(s):
Evan L. Flatow, M.D., Professor and Chair, Department of Orthopaedics
Markers of tumor stem cells and tumor cell signal transduction
Training Area(s):
Type(s) of Research:
Research Topic(s):
Anti-Tumor Therapy, Apoptosis/Cell Death, Cancer, Signal Transduction
Paul S. Frenette, M.D., Associate Professor, Department of Medicine
Adhesion mechanisms regulating hematopoiesis and the pathophysiology of sickle cell disease
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Cell Adhesion, Endothelial Cells, Glycobiology, Hematopoiesis, Inflammation, Knockout Mice, Stem Cells
Clinical Research Topic(s):
Translational research
Scott L. Friedman, M.D., Professor, Department of Medicine
Role of KLF6 tumor suppressor gene in cancer pathogenesis; molecular regulation of hepatic fibrosis; Testing of novel antifibrotic therapies in preclinical models and human trials
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Aerodigestive Tract, Apoptosis/Cell Death, Cancer Genetics, Cell Biology, Cell Transformation, Developmental Biology, Epithelial Cells, Extracellular Matrix, Fibrosis, Growth Factors and Receptors, Hepatitis C Virus, Integrins, Knockout Mice, Liver, Macrophage, Metastasis, Molecular Biology, Organogenesis, Oxidative Stress, Phosphorylation, Proteases, Receptors, Signal Transduction, Stem Cells, Transcription Factors, Transcriptional Activation and Repression, Transgenic Mice, Tumor Suppressor Genes, Tumorigenesis, Vascular Development, Wound Healing
Clinical Research Topic(s):
Patient-oriented research, Translational research
Janice L. Gabrilove, M.D., Professor, Department of Medicine
Training Area(s):
Type(s) of Research:
Research Topic(s):
Samuel E. Gandy, M.D., Professor, Department of Neurology
Training Area(s):
Type(s) of Research:
Research Topic(s):
Adolfo Garcia-Sastre, Ph.D., Professor, Department of Microbiology
Molecular Biology of RNA viruses
Training Area(s):
Type(s) of Research:
Research Topic(s):
Antivirals, Biodefense, Cellular Immunity, Cytokines, Gene Expressions, Gene Regulation, Gene Therapy, Immune Antagonism, Infectious Disease, Influenza Virus, Interferon, Interferon Antagonists, Interferon Resistance, Molecular Biology, Paramyxovirus, RNA, RNA Splicing & Processing, RNA Transport & Localization, Trafficking, Transcription Factors, Transcriptional Activation and Repression, Vaccine Development, Virulence Genes, Viruses and Virology
Bruce D. Gelb, M.D., Professor, Department of Genetics and Genomic Sciences
Genetics of congenital heart defects; Noonan syndrome and related disorders; Gain-of-function RAS signaling
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cardiovascular, Gene Discovery, Human Genetics and Genetic Disorders, Signal Transduction, Stem Cells, Transgenic Mice
Doris Germain, Ph.D., Associate Professor, Department of Medicine (Hematology and Medical Oncology)
Role of cyclins in prognosis of breast cancer; pregnancy-associated breast cancer; role of estrogen receptor in the mitochondria.
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Cancer, Cell Cycle, Hormones, Mitochondria, Oncogenes, Protein Degradation, Protein Folding, Receptors
Isabelle M. Germano, M.D., Professor, Department of Neurosurgery
molecular biology and translational research of primary brain tumor, embryonic stem cell differentiation and gene therapy for brain tumors
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Anti-Tumor Therapy, Apoptosis/Cell Death, Autophagy, Brain, Cancer, Cellular Differentiation, Gene Expressions, Gene Therapy, Metastasis, Migration, Molecular Biology, Neuroscience, Seizure, Stem Cells, Translation, Tumor Suppressor Genes, Tumorigenesis
Clinical Research Topic(s):
Translational research
Saghi Ghaffari, M.D., Ph.D., Assistant Professor, Department of Gene and Cell Medicine
Molecular Mechanisms of Regulation of Hematopoietic Stem and Progenitor Cell Fate
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cancer, Cell Transformation, Cellular Differentiation, Hematopoiesis, Leukemia, Oncogenes, Oxidative Stress, Signal Transduction, Stem Cells, Transcription Factors
Gabriele L. Gusella, Ph.D., Assistant Professor, Department of Medicine (Nephrology)
Molecular mechanisms of renal cystogenesis
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cancer, Cell Adhesion, Cell Biology, Cell Cycle, Cell Division, Developmental Biology, Epithelial Cells, Extracellular Matrix, Genetics, Human Genetics and Genetic Disorders, Integrins, Kidney, Microtubules, Mitosis, Molecular Biology, Retrovirus
Roger J. Hajjar, M.D., Professor, Department of Medicine (Cardiology)
Cardiology
Training Area(s):
Type(s) of Research:
Research Topic(s):
Simon Hall, M.D., Associate Professor, Department of Urology
Gene therapy for prostate cancer
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Gene Therapy
Clinical Research Topic(s):
Translational research
Basil G. Hanss, Ph.D., Assistant Professor, Department of Medicine
Mechanisms of plasma membrane nucleic acid transport
Training Area(s):
Type(s) of Research:
Research Topic(s):
Gene Therapy, Intracellular Transport, Kidney, Membrane Proteins/Channels, Protein Complexes, Protein Structure/Function, Transporters
Vahram Haroutunian, Ph.D., Professor, Department of Psychiatry
Neurobiology of Alzheimer's disease and Schizophrenia
Training Area(s):
Type(s) of Research:
Research Topic(s):
Alzheimer's Disease, Glutamate (NMDA & AMPA) Receptors, Myelination, Neurotransmitters, RNA, Schizophrenia
Erin A. Hazlett, Ph.D., Associate Professor, Department of Psychiatry
Imaging, Schizophrenia and Other Psychiatric Disorders, Anatomy and Neuroanatomy, Neurophysiology
Training Area(s):
Type(s) of Research:
- Clinical Research
- Translational Research
Research Topic(s):
Brain, Brain Imaging, Cognitive Neuroscience, Magnetic Resonance Imaging, Neuroscience, Positron Emission Tomography, Prefrontal Cortex, Schizophrenia, Thalamus
Peter S. Heeger, M.D., Professor, Department of Medicine (Nephrology)
Transplant immunology, complement, T cells
Training Area(s):
Type(s) of Research:
Research Topic(s):
Immunology, T Cells, Transplantation
Jeanne P. Hirsch, Ph.D., Associate Professor, Department of Pharmacology and Systems Therapeutics
Signal transduction pathways mediated by heterotrimeric G proteins in the yeast Saccharomyces cerevisiae
Training Area(s):
Type(s) of Research:
Research Topic(s):
Aging, cAMP, Fungal Pathogenesis, Genetics, Morphogenesis, Protein Kinases, Protein Phosphatases, Protein Structure/Function, Signal Transduction
Patrick R. Hof, M.D., Professor, Department of Neuroscience
Experimental neuropathology, neurodegenerative disorders, brain aging; Functional anatomy of the cerebral cortex, comparative neuroanatomy; Computer-assisted morphometry, stereology, microscopy; Magnetic resonance microscopy, functional brain imaging
Training Area(s):
Type(s) of Research:
Research Topic(s):
Aging, Brain, Brain Imaging, Cerebral Cortex, Comparative Anatomy, Demyelination, Diffusion Tensor Imaging, Evolution, Glutamate (NMDA & AMPA) Receptors, Hippocampus, Image Analysis, Magnetic Resonance Imaging, Memory, Mental Retardation, Morphometrics, MRI, Neurobiology, Neuro-degeneration/protection, Neuroscience, Quantitative Neuroanatomy, Schizophrenia, Synapses, Systems Neuroscience, Thalamus
Gay R. Holstein, Ph.D., Associate Professor, Department of Neurology
Neuronanatomical studies of functionally-defined central and peripheral vestibular system structures
Training Area(s):
Type(s) of Research:
Research Topic(s):
Brain, Image Analysis, Imaging, Inner Ear, Neurotransmitters, Receptors, Synapses, Systems Neuroscience, Vestibular
George W. Huntley, Ph.D., Associate Professor, Department of Neuroscience
Development, Plasticity and Repair of Synaptic Circuit Structure and Function
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Axon Guidance, Brain, Cell Adhesion, Cerebral Cortex, Developmental Neurobiology, Memory, Neurophysiology, Neurotransmitters, Regeneration, Spinal Cord, Synapses, Synaptic Plasticity, Synaptogenesis
Yasmin Hurd, Ph.D., Professor, Department of Psychiatry
Opioid neuropeptide, cannabinoid and dopamine neural systems in drug abuse
Training Area(s):
Type(s) of Research:
Research Topic(s):
Addiction, Basal Ganglia, Behavior, Brain, Developmental Biology, Gene Regulation, Genetics, Neuropeptides, Neuroscience, Neurotransmitters, Opioid/Cannabinoid Receptors
Yiannis A. Ioannou, Ph.D., Associate Professor, Department of Genetics and Genomic Sciences
Molecular genetics
Training Area(s):
Type(s) of Research:
Research Topic(s):
Apoptosis/Cell Death, Atherosclerosis, Brain, Cardiovascular, Caveoloe, Diabetes, Gene Regulation, Gene Therapy, Genetics, Human Genetics and Genetic Disorders, Intracellular Transport, Lipid Signaling, Lysosomal Storage Diseases, Lysosomes/endosome, Mass Spectrometry, Membrane Proteins/Channels, Membranes, Mental Retardation, Obesity, Protein Complexes, Protein Degradation, Protein Kinases, Protein Phosphatases, Protein Structure/Function, Protein Trafficking & Sorting, Proteomics, RNA, Transporters
Ravi Iyengar, Ph.D., Professor and Chair, Department of Pharmacology and Systems Therapeutics
Cellular signaling systems with emphasis on heterotrimeric G proteins
Training Area(s):
Type(s) of Research:
Research Topic(s):
Addiction, Axonal Growth and Degeneration, Bioinformatics, cAMP, Cell Adhesion, Cell Biology, Cell Motility, Cell Transformation, Computational Biology, Computer Simulation, Cytoskeleton, Dendritic Cells, Drug Design and Discovery, Hippocampus, Mathematical and Computational Biology, Mathematical Modeling of Biomedical Systems, Membranes, Memory, Nanotechnology, Phosphorylation, Protein Kinases, Protein Phosphatases, Proteomics, Receptors, Signal Transduction, Synaptic Plasticity, Theoretical Biology, Transcription Factors
Karl J. Jepsen, Ph.D., Associate Professor, Department of Orthopaedics
The genetic and mechanical basis of skeletal fragility; damage mechanics in bone; aging of skeletal tissues; clinical indicators of osteoporosis; systems biology
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Biomechanics/Bioengineering, Bone Biology, Computed Tomography, Genetics, Genomics, Growth, Image Analysis, Imaging, Osteoporosis, Skeletal Biology
Clinical Research Topic(s):
Translational research
Gareth R. John, Ph.D., Assistant Professor, Department of Neurology
CNS, glia, astrocyte, inflammation, injury, repair
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Brain, Cytokines, Immunology, Inflammation, Multiple Sclerosis, Myelination, Neurobiology, Regeneration
Ehud Kaplan, Ph.D., Professor, Department of Neuroscience
Neurophysiology; visual neuroscience
Training Area(s):
Type(s) of Research:
Research Topic(s):
Brain Imaging, Computational Neuroscience, Computer Simulation, Image Analysis, Imaging, Neural Code, Neurobiology, Neurophysiology, Retina, Systems Neuroscience, Vision
Kevin Kelley, Ph.D., Professor, Department of Developmental and Regenerative Biology
Creation of animal models for the study of gene regulation, gene function and human diseases
Training Area(s):
Type(s) of Research:
Research Topic(s):
Developmental Biology, DNA Recombination, Embryology, Gene Regulation, Genetics, Knockout Mice, Molecular Biology, Reproductive Biology, Transgenic Mice
Mary E. Klotman, M.D., Professor, Department of Medicine
Molecular pathogenesis and therapy of HIV
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
AIDS/HIV, Chemokines, Drug Design and Discovery, Immunology, Infectious Disease, Macrophage, Protein Phosphatases, Retrovirus, Signal Transduction, T Cells, Transcriptional Activation and Repression, Viruses and Virology
Clinical Research Topic(s):
Translational research
Paul E. Klotman, M.D., Professor and Chair, Department of Medicine
HIV pathogenesis; HIV associated nephropathy; renal diseases; podoocan; sidekick
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
AIDS/HIV, Angiogenesis, Antivirals, Apoptosis/Cell Death, Bone Metabolism, Cell Biology, Chemokines, Cytoskeleton, Developmental Biology, Endothelial Cells, Epithelial Cells, Gene Discovery, Gene Expressions, Gene Regulation, Gene Therapy, Infectious Disease, Kidney, Knockout Mice, Molecular Biology, Osteoporosis, Pathology, Retrovirus, Virulence Genes, Viruses and Virology
Clinical Research Topic(s):
Translational research
Robert S. Krauss, Ph.D., Professor, Department of Developmental and Regenerative Biology
Cell Adhesion and Signal Transduction in Pattern Formation and Cell Differentiation During Development
Training Area(s):
Type(s) of Research:
Research Topic(s):
Genetics, Human Genetics and Genetic Disorders, Muscle Cells, Muscular Dystrophy, Oncogenes, Axon Guidance, Cancer, Cell Adhesion, Cellular Differentiation, Cytoskeleton, Developmental Biology
Terry Ann Krulwich, Ph.D., Professor, Department of Pharmacology and Systems Therapeutics
Bacterial cation transport systems: antiporters that support bacterial resistance to toxic cations and anions; ion-translocating complexes that support extreme alkaliphily; transporters involved in Bacillus anthracis spore germination
Training Area(s):
Type(s) of Research:
Research Topic(s):
Anthrax, Antibiotic Resistance, Membrane Proteins/Channels, Transporters
Jeffrey T. Laitman, Ph.D., Professor , Center for Anatomy and Functional Morphology
Development and evolution of the mammalian aerodigestive system; vocal tract development; evolutionary origins of speech
Training Area(s):
Type(s) of Research:
Research Topic(s):
Aerodigestive Tract, Anatomy, Comparative Anatomy, Developmental Biology, Evolution, Growth, Language, Larynx, Respiratory Tract, Speech, Vocal Tract
Emmanuel M. Landau, M.D., Ph.D., Professor, Department of Psychiatry
Synaptic signaling and plasticity
Training Area(s):
Type(s) of Research:
Research Topic(s):
Hippocampus, Memory, Neurobiology, Protein Translation, RNA Transport & Localization, Signal Transduction, Synaptic Plasticity
Djamel Lebeche, Ph.D., Assistant Professor, Department of Medicine
Training Area(s):
Type(s) of Research:
Research Topic(s):
Ihor Lemischka, Ph.D., Professor, Department of Gene and Cell Medicine
Training Area(s):
Type(s) of Research:
Research Topic(s):
Derek LeRoith, M.D., Ph.D., Chief, Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine (Endocrinology)
The role of insulin and the insulin-like growth factors in pathological states including diabetes, growth, bone disorders and cancer.
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Cancer, Diabetes, Growth
Clinical Research Topic(s):
Translational research
Xiajun (John) Li, Ph.D., Assistant Professor, Department of Developmental and Regenerative Biology
Acquisition and maintenance of DNA methylation genomic imprints. A maternal-zygotic effect gene in mouse. LIN-12/Notch signaling in cardiovascular development. Maintenance and differentiation of embryonic stem cells.
Training Area(s):
Type(s) of Research:
Research Topic(s):
Developmental Biology, Epigenetics, Genetics, Stem Cells, Transgenic Mice
Xiu-min Li, M.D., Associate Professor, Department of Pediatrics
Mechanisms of allergic diseases, food allergy and allergic asthma, developing novel therapies for treating diseases
Training Area(s):
Type(s) of Research:
Research Topic(s):
Allergy, B Cells, cAMP, Cellular Immunity, Cytokines, Immunological Tolerance, Immunology, Inflammation, Lymphocytes, Memory, T Cells
Reigh-Yi Lin, Ph.D., Assistant Professor, Department of Medicine
Developmental Biology, Stem Cell, Thyroid
Training Area(s):
Type(s) of Research:
Research Topic(s):
Developmental Biology, Stem Cells, Thyroid
Michael S. Lipkowitz, M.D., Associate Professor, Department of Medicine (Nephrology)
Cell biology, proteomics and genetics of hyperuricemia and progressive kidney disease
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Cardiovascular, Genetics, Kidney, Proteomics, Transporters, Uric Acid
Clinical Research Topic(s):
Translational research
Sergio A. Lira, M.D., Ph.D., Professor, Department of Medicine
Chemokines; leukocyte trafficking; angiogenesis; lymphoid development; mouse genetics
Training Area(s):
Type(s) of Research:
Research Topic(s):
Angiogenesis, Autoimmunity, Brain, Chemokines, Chemotaxis, Demyelination, Diabetes, Endothelial Cells, Immunology, Inflammation, Macrophage, Multiple Sclerosis, Stem Cells, T Cells, Thyroid, Viruses and Virology
Carolina Lopez, Ph.D., Assistant Professor, Department of Microbiology
Host-pathogen interactions; viral immunology
Training Area(s):
Type(s) of Research:
Research Topic(s):
Fred Lublin, M.D., Professor, Department of Neurology
Multiple Sclerosis
Training Area(s):
Research Topic(s):
Multiple Sclerosis
Zhongmin Ma, Ph.D., Assistant Professor, Department of Geriatrics and Adult Development
Phospholipid signaling in pancreatic beta-cell function, apoptosis, and regeneration; cell membrane homeostasis and cell cycle checkpoint regulation; molecular pathogenesis of infantile neuroaxonal dystrophy
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cell Biology, Cell Cycle, Chemotaxis, Diabetes, Lipid Signaling, Membranes, Mitochondria, Molecular Biology, Neuroscience, Oxidative Stress
Avi Ma'ayan, Ph.D., Assistant Professor, Department of Pharmacology and Systems Therapeutics
Computational systems biology, bioinformatics, graph theory application to biological networks, software engineering and artificial intelligence application to systems biology
Training Area(s):
Type(s) of Research:
Research Topic(s):
Bioinformatics, Biophysics, Biostatistics, Cell Adhesion, Cell Biology, Cellular Differentiation, Computational Biology, Computational Neuroscience, Computer Simulation, Dendritic Cells, Diabetes, Drug Design and Discovery, Gene Expressions, Gene Regulation, Mathematical and Computational Biology, Mathematical Modeling of Biomedical Systems, Microarray, Molecular Biology, Nanotechnology, Neural Networks, Protein Complexes, Protein Kinases, Protein Phosphatases, Proteomics, Retinoic Acid, Stem Cells, Theoretical Biology, Theoretical Biophysics, Theoretical Neuroscience
Saul Maayani, Ph.D., Professor, Department of Anesthesiology
Human blood platelets as a system for studying membrane receptors and their effectors
Training Area(s):
Research Topic(s):
James J. Manfredi, Ph.D., Associate Professor, Department of Oncological Sciences
Molecular basis of p53 tumor suppressor activity
Training Area(s):
Type(s) of Research:
Research Topic(s):
Apoptosis/Cell Death, Cancer, Cell Cycle, Cell Division, Gene Regulation, Metastasis, Mitosis, Molecular Epidemiology, Nucleus, Oncogenes, Phosphorylation, Prostate, Protein Structure/Function, Transcription Factors, Transcriptional Activation and Repression, Viruses and Virology
Robert F. Margolskee, M.D., Ph.D., Professor, Department of Neuroscience
Molecular, transgenic and structural techniques to study peripheral and central mechanisms of taste transduction and coding to determine how these pathways regulate gustatory behaviors in vivo
Training Area(s):
Type(s) of Research:
Research Topic(s):
Genomics, Membrane Proteins/Channels, Signal Transduction, Stem Cells, Structural Biology
John A. Martignetti, M.D., Ph.D., Associate Professor, Department of Genetics and Genomic Sciences
Genomics, molecular biology, cancer genetics, gene discovery, hereditary cancers, cancer syndromes, tumor suppressor genes, linkage analysis
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cancer Genetics, Gene Discovery, Genomics, Molecular Biology, Tumor Suppressor Genes
Sandra K. Masur, Ph.D., Professor, Department of Ophthalmology
Cell-cell and cell-matrix interaction during wound healing
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cell Adhesion, Cellular Differentiation, Cytoskeleton, Extracellular Matrix, Growth Factors and Receptors, Integrins, Migration, Proteases, Wound Healing
Marianna Max, Ph.D., Assistant Professor, Department of Neuroscience
G-protein coupled receptors for sweet taste transduction.
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Biophysics, Brain, Mathematical and Computational Biology, Mathematical Modeling of Biomedical Systems, Membrane Proteins/Channels, Neurobiology, Neurophysiology, Protein Structure/Function, Receptors, Signal Transduction, Structural Biology, Theoretical Biophysics
Clinical Research Topic(s):
Translational research
Lloyd F. Mayer, M.D., Professor, Center for Immunobiology
Regulation of mucosal immune responses; antigen presentation by intestinal epithelial cells
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Antigen Presentation, Epithelial Cells, Lymphocytes, Mucosal Immunology
Clinical Research Topic(s):
Translational research
Kevin St.P. McNaught, Ph.D., Assistant Professor, Department of Neurology
The cause and mechanism of neuronal death in neurodegenerative disorders
Training Area(s):
Type(s) of Research:
Research Topic(s):
Apoptosis/Cell Death, Basal Ganglia, Brain, Neurobiology, Neuro-degeneration/protection, Neuroscience, Neurotoxicology, Parkinson's Disease, Proteases, Protein Degradation
Miriam Merad, M.D., Ph.D., Assistant Professor, Department of Gene and Cell Medicine
Ontogeny and homeostasis of Langerhans cells; role of Langerhans cells in skin graft versus host disease (GVHD)
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cancer, Chemokines, Immunological Tolerance, Immunology, Stem Cells, T Cells, Transplantation
Mihaly Mezei, Ph.D., Associate Professor, Department of Structural and Chemical Biology
Computer simulation of aqueous systems; methodology and biomolecular applications
Training Area(s):
Type(s) of Research:
Research Topic(s):
Computer Simulation, Protein Structure/Function
Marek Mlodzik, Ph.D., Professor, Department of Developmental and Regenerative Biology
Cell-cell interactions during epithelial and nervous system patterning: planar polarity establishment
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cell Biology, Cellular Differentiation, Cytoskeleton, Developmental Neurobiology, Drosophila, Genetics, Genomics, Growth Factors and Receptors, Oncogenes, Signal Transduction
Charles V. Mobbs, Ph.D., Associate Professor, Department of Neuroscience
Aging; obesity; diabetes; Alzheimer's disease; life extension; dietary restriction;
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Adipose, Aging, Behavior, Brain, Diabetes, Hormones, Insulin, Knockout Mice, Memory, Mitochondria, Neuro-degeneration/protection, Neurotoxicology, Obesity, Oxidative Stress, Transcription Factors, Transgenic Mice
Kateri A. Moore, DVM, Associate Professor, Department of Gene and Cell Medicine
Stem Cells/Microenvironment/Stem Cell NIche, Cell, Developmental, Molecular regulation of hematopoietic stem cell self renewal and differentiation, molecular interaction of stem cells and microenvironmental elements, ie. the stem cell niche regulation of stem cells.
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Gene Discovery, Genomics, Hematopoiesis, Molecular Biology, Stem Cells
Steven T. Moore, Ph.D., Assistant Professor, Department of Neurology
posture and gait; vestibular system; microgravity effects; Parkinson's disease (locomotor assessment)
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Locomotion, Motor Control, Parkinson's Disease, Postural Control, Vestibular, Vision
Clinical Research Topic(s):
Patient-oriented research, Translational research
Thomas M. Moran, Ph.D., Professor, Department of Microbiology
Immune response to virus infection Viruses used: -Influenza, Newcastle Disease, and Sendai Models used: -mouse (in vivo, in-vitro, and ex-vivo) -human (in-vitro) cells isolated from human donors Cell types currently studied: -PBMCs, Monocytes, Dendritic cells, (cDCs & mDCs) Topics of interest: Effect of cytokine release on: -inflammation -trafficking Study of In VItro Immune response of cells isolated from pregnant donors to various laboratory viruses
Training Area(s):
Type(s) of Research:
Research Topic(s):
Antigen Presentation, B Cells, Cellular Immunity, Cytokines, Dendritic Cells, Immune Antagonism, Immunoglobulin Genes, Immunological Tolerance, Immunology, Infectious Disease, Inflammation, Interferon, T Cells, Transplantation, Vaccine Development, Viruses and Virology
Susan Morgello, M.D., Professor, Department of Pathology
hiv/aids; neuropathology; clinicopathologic correlates
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
AIDS/HIV, Brain
Clinical Research Topic(s):
Patient-oriented research, Translational research
John H. Morrison, Ph.D., Professor, Department of Neuroscience
Neurobiology of aging, plasticity, and cortical organization. Steroid effects on cortical circuitry and function.
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Aging, Alzheimer's Disease, Brain, Cognitive Neuroscience, Cytoskeleton, Epigenetics, GABA, Glutamate (NMDA & AMPA) Receptors, Hormones, Membrane Proteins/Channels, Memory, Motor Neuron, MRI, Neural Networks, Neurobiology, Neuroscience, Neurotransmitters, Protein Trafficking & Sorting, Receptors, Regeneration, Reproductive Biology, RNA Transport & Localization, Signal Transduction, Synapses, Synaptic Plasticity, Synaptogenesis, Systems Neuroscience, Transgenic Mice, Transporters, Vision
Clinical Research Topic(s):
Translational research
Goutham Narla, M.D., Ph.D., Assistant Professor, Department of Medicine
Role of tumor suppressor and oncogenes in tumorigenesis and metastasis; genetics of chemotherapy resistance
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Cancer Genetics, Metastasis, Oncogenes, Transgenic Mice, Tumor Suppressor Genes, Tumorigenesis
Eric J. Nestler, M.D., Ph.D., Professor and Chair, Department of Neuroscience
Molecular neurobiology of drug addiction and depression; transcriptional and epigenetic regulation in the brain.
Training Area(s):
Type(s) of Research:
Research Topic(s):
Addiction, Behavior, Epigenetics, Molecular Biology, Neuroscience
Natalia Nieto, Ph.D., Assistant Professor, Department of Medicine (Liver Diseases)
Crosstalk between Kupffer cells and stellate cells and the fibrogenic response in the liver.
Training Area(s):
Type(s) of Research:
Research Topic(s):
Extracellular Matrix, Fibrosis, Liver, Oxidative Stress
Matthew J. O'Connell, Ph.D., Associate Professor, Department of Oncological Sciences
Regulation of the cell cycle; control over genomic stability and chromosome dynamics; the design of novel strategies for anti-cancer therapies
Training Area(s):
Type(s) of Research:
Research Topic(s):
Apoptosis/Cell Death, Cancer, Cell Cycle, Cell Division, Chromatin, DNA Recombination, DNA Repair, DNA Replication, Genetics, Leukemia, Mitosis, Nucleus, Oncogenes, Phosphorylation, Protein Complexes, Protein Degradation, Protein Kinases, Protein Phosphatases, Protein Structure/Function
Roman Osman, Ph.D., Professor, Department of Structural and Chemical Biology
Molecular theoretical biophysics of enzymatic DNA repair; alosterism and cooperativity in the blood coagulation pathway; molecular mechanism of autoimmune diseases; protein folding
Training Area(s):
Type(s) of Research:
Research Topic(s):
Antigen Presentation, Biophysics, Computational Biology, Computer Simulation, DNA Repair, Membrane Proteins/Channels, Protein Folding, Protein Structure/Function, Receptors, Theoretical Biophysics
Liliana Ossowski, Ph.D., Professor, Department of Medicine
Proteases in cancer metastasis, tumor dormancy, receptors, integrins
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cancer, Metastasis
Laurie Ozelius, Ph.D., Associate Professor, Department of Genetics and Genomic Sciences
Genetics of Movement Disorders, Parkinson's Disease, Dystonia, Basal Ganglia, Brain, Linkage Analysis, Association Studies, Pentrance, Haplotype, Molecular Biology
Training Area(s):
Type(s) of Research:
Research Topic(s):
Basal Ganglia, Brain, Gene Discovery, Genetics, Human Genetics and Genetic Disorders, Molecular Biology, Parkinson's Disease, Genetics of Movement disorders
Peter Palese, Ph.D., Professor, Department of Microbiology
Host-virus interactions; vaccines and antivirals; virulence factors of RNA viruses
Training Area(s):
Type(s) of Research:
Research Topic(s):
Antivirals, Apoptosis/Cell Death, Biodefense, Coronavirus, Influenza Virus, Interferon, Interferon Antagonists, Nipah Virus, Paramyxovirus, RNA, SARS Virus, Vaccine Development, Virulence Genes, Viruses and Virology
Zhen-Qiang Pan, Ph.D., Professor, Department of Oncological Sciences
Ubiquitin signaling in cancer biology
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cancer, Enzymology, Protein Degradation, Signal Transduction
Giulio M. Pasinetti, M.D., Ph.D., Professor, Department of Psychiatry
Neuronal Degeneration in Alzheimers Disease and Model System
Training Area(s):
Type(s) of Research:
Research Topic(s):
Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Brain, Diabetes, Gene Therapy, Genomics, Inflammation, Insulin, Memory, Microarray, Muscular Dystrophy, Obesity, Proteomics, Synapses, Viruses and Virology
Cathie Pfleger, Ph.D., Assistant Professor, Department of Oncological Sciences
How the processes of growth and proliferation are regulated and how loss of that regulation leads to cancer, with a special emphasis on regulation by the ubiquitin pathway.
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cancer, Cell Cycle, Developmental Biology, Drosophila, Gene Discovery, Growth, Oncogenes, Phosphorylation, Protein Degradation, Signal Transduction, Tumor Suppressor Genes, Tumorigenesis
Greg R. Phillips, Ph.D., Assistant Professor, Department of Neuroscience
Identification and characterization of synaptic adhesive and recognition proteins
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cell Adhesion, Cell Biology, Extracellular Matrix
Stella Plevan, Ph.D., Associate Professor, Department of Psychiatry
1. Role of Serotonin 2C Receptor mRNA Editing in Psychiatric Conditions (Suicide, Drug Addiction) 2. Molecular Abnormalities in the Brain of Schizophrenia Patients
Training Area(s):
Type(s) of Research:
Research Topic(s):
Addiction, Gene Expressions, Receptors, Schizophrenia
Isak Prohovnik, Ph.D., Professor, Department of Psychiatry
Functional & structural neuroimaging; CJD; AD
Training Area(s):
Type(s) of Research:
- Clinical Research
- Translational Research
Research Topic(s):
Aging, Alzheimer's Disease, Bioinformatics, Brain, Cognitive Neuroscience, Drug Design and Discovery, Imaging, Magnetic Resonance Imaging, Memory, Neuro-degeneration/protection
Preeti Raghavan, M.D., Assistant Professor, Department of Rehabilitation Medicine
Recovery of motor control after stroke, brain injury
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Behavior, Brain, Motor Control, Neuromuscular System, Neuroscience
Clinical Research Topic(s):
Translational research
Francesco Ramirez, D.Sc., Professor, Department of Pharmacology and Systems Therapeutics
Connective tissue in morphogenesis and diseased conditions; extracellular regulation of TGFb and BMP signaling; Marfan syndrome and scleroderma.
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cardiovascular, Cell Biology, Extracellular Matrix, Genetics, Growth Factors and Receptors, Knockout Mice, Molecular Biology, Organogenesis, Skeletal Biology
Gwendalyn J. Randolph, Ph.D., Associate Professor, Department of Gene and Cell Medicine
Differentiation and migration of dendritic cells
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Antigen Presentation, Atherosclerosis, Cell Adhesion, Chemokines, Chemotaxis, Dendritic Cells, Endothelial Cells, Immunology, Inflammation, Lung, Macrophage, Migration, Pathology, Tissue Engineering, Vaccine Development
Clinical Research Topic(s):
Translational research
Michael Rendl, M.D., Assistant Professor, Department of Developmental and Regenerative Biology
Cell fate specification of stem cell niche cells during hair morphogenesis; stem cell activation by dermal papilla niche cells during hair formation and regeneration
Training Area(s):
Type(s) of Research:
Research Topic(s):
Bioinformatics, Developmental Biology, Gene Expressions, Gene Regulation, Genomics, Knockout Mice, Morphogenesis, Organogenesis, Regeneration, Stem Cells, Transcription Factors, Transgenic Mice
Nikolaos K. Robakis, Ph.D., Professor, Department of Psychiatry
Mechanisms of Neurodegeneration; Signal transduction; aexpression, processing, and function of APP and presenilins
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Aging, Alzheimer's Disease, Apoptosis/Cell Death, Brain, Cell Adhesion, Memory, Molecular Biology, Neurobiology, Neuro-degeneration/protection, Neuroscience, Signal Transduction, Synapses
Clinical Research Topic(s):
Translational research
Michael J. Ross, M.D., Assistant Professor, Department of Medicine (Nephrology)
The pathogenesis of renal epithelial disease in HIV-associated nephropathy; the role of FAT10 in the pathogenesis of kidney disease.
Training Area(s):
Type(s) of Research:
Research Topic(s):
AIDS/HIV, Apoptosis/Cell Death, Cell Cycle, Kidney
Scott Russo, Ph.D., Assistant Professor, Department of Neuroscience
Training Area(s):
Type(s) of Research:
Research Topic(s):
Scott J. Russo, Ph.D., Assistant Professor, Department of Neuroscience
Training Area(s):
Type(s) of Research:
Research Topic(s):
Kirsten Sadler-Edepli, Ph.D., Assistant Professor, Department of Developmental and Regenerative Biology
Using zebrafish to understand liver development, regeneration and disease
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cancer, Cell Biology, Developmental Biology, Diabetes, Embryology, Genetics, Liver, Morphogenesis, Obesity, Organogenesis, Oxidative Stress, Regeneration, Tumorigenesis
Takeshi Sakurai, M.D. Ph.D., Assistant Professor, Department of Psychiatry
My research interest has been how nervous system develops at the molecular level, i.e., molecular mechanisms of wiring and synapse formation, and how alterations in these processes lead to neurological and pscyhiatric disorders
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Addiction, Anatomy, Autism, Axon Guidance, Axonal Growth and Degeneration, Basal Ganglia, Behavior, Bioinformatics, Brain, Cell Adhesion, Cell Biology, Cerebellum, Cerebral Cortex, Demyelination, Developmental Neurobiology, Epilepsy, Extracellular Matrix, Genetics, Genomics, Glutamate (NMDA & AMPA) Receptors, Glycobiology, Growth Cone, Knockout Mice, Mental Retardation, Microarray, Molecular Biology, Multiple Sclerosis, Myelination, Neural Networks, Neurobiology, Neuroscience, Prefrontal Cortex, Protein Kinases, Protein Phosphatases, Retina, Schizophrenia, Seizure, Signal Transduction, Spinal Cord, Stem Cells, Synapses, Synaptogenesis, Transgenic Mice
Clinical Research Topic(s):
Translational research
Stephen R.J. Salton, M.D., Ph.D., Associate Professor, Department of Neuroscience
Molecular neurobiology; neurotrophin signaling; novel neuropeptides and obesity; neural cell adhesion molecules
Training Area(s):
Type(s) of Research:
Research Topic(s):
Adipose, Aging, Apoptosis/Cell Death, Axon Guidance, Brain, Cell Adhesion, Chromogranins and Secretogranins, Cytoskeleton, Diabetes, Growth Cone, Growth Factors and Receptors, Hormones, Neuropeptides, Neurotrophins, Obesity, Protein Phosphatases, Protein Trafficking & Sorting, Signal Transduction, Synapses
Hugh A. Sampson, M.D., Professor, Department of Pediatrics
Immunopathogenic mechanisms of food allergic disorders and asthma; immunomodulatory therapies
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Allergy, B Cells, Immunological Tolerance, T Cells
Clinical Research Topic(s):
Translational research
Roberto Sanchez, Ph.D., Assistant Professor, Department of Structural and Chemical Biology
Bioinformatics; computational analysis of structure and function of proteins and genomes
Training Area(s):
Type(s) of Research:
Research Topic(s):
Bioinformatics, Drug Design and Discovery, Protein Structure/Function, Structural Biology
Lisa M. Satlin, M.D., Professor, Department of Pediatrics
Mechanoregulation of epithelial ion channels and transporters in kidney in health and disease; ontogeny of renal ion channels
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Biomechanics/Bioengineering, Cell Biology, Cellular Differentiation, Cytoskeleton, Developmental Biology, Electrophysiology, Epithelial Cells, Gene Expressions, Growth, Growth Factors and Receptors, Hormones, Imaging, Kidney, Knockout Mice, Membrane Proteins/Channels, Membranes, Phosphorylation, Protein Complexes, Protein Kinases, Protein Phosphatases, Protein Trafficking & Sorting, Signal Transduction, Trafficking, Transporters, Two-Photon Imaging
Clinical Research Topic(s):
Translational research
David A. Savitz, Ph.D., Professor, Department of Community and Preventive Medicine
environmental , social, and behavioral influences on reproductive health outcomes, including preterm birth and miscarriage, and influences on neurobehavioral development in chidlren
Training Area(s):
Type(s) of Research:
Research Topic(s):
Biostatistics, Cancer, Diabetes, Embryology
Clinical Research Topic(s):
Epidemiologic research
Edward H. Schuchman, Ph.D., Professor, Department of Genetics and Genomic Sciences
The biology and treatment of lysosomal storage disorders; the role of lipid hydrolases in cell signaling
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Angiogenesis, Apoptosis/Cell Death, Blood-Brain Barrier, Bone Metabolism, Brain, Cancer, Cardiovascular, Cartilage Biology, Cellular Differentiation, Chemokines, Chemotaxis, Cytokines, Endothelial Cells, Enzymology, Fibrosis, Gene Regulation, Gene Therapy, Genetics, Genomics, Human Genetics and Genetic Disorders, Inflammation, Lipid Signaling, Lysosomal Storage Diseases, Lysosomes/endosome, Macrophage, Mental Retardation, Metastasis, Neuro-degeneration/protection, Protein Trafficking & Sorting, Reproductive Biology, Signal Transduction, Stem Cells, Tumorigenesis
Stuart C. Sealfon, M.D., Professor and Chair, Department of Neurology
Systems biology of cellular signaling specificity in response to drugs or viruses
Training Area(s):
Type(s) of Research:
Research Topic(s):
Addiction, Apoptosis/Cell Death, Basal Ganglia, Bioinformatics, Brain, Cellular Immunity, Cerebral Cortex, Mathematical and Computational Biology, Neuro-degeneration/protection, Receptors, Reproductive Biology, Signal Transduction, Theoretical Biology, Vaccine Development, Viruses and Virology
Matthew Shapiro, Ph.D., Associate Professor, Department of Neuroscience
Memory and brain: how experience alters activity and changes circuit function
Training Area(s):
Type(s) of Research:
Research Topic(s):
Aging, Behavior, Electrophysiology, Neural Networks
Pullanipally Shashidharan, Ph.D., Associate Professor, Department of Neurology
Neurobiology of Dystonia, Parkinson's disease and other movement disorders
Training Area(s):
Type(s) of Research:
Research Topic(s):
Brain, Gene Regulation, Gene Therapy, Neuro-degeneration/protection
Megan Shaw, Ph.D., Assistant Professor, Department of Microbiology
Requirement of host factors for virus replication and pathogenesis
Training Area(s):
Type(s) of Research:
Research Topic(s):
Antivirals, Biodefense, Influenza Virus, Interferon Antagonists, Nipah Virus, Proteomics, Viruses and Virology
Phyllis A. Shaw, Ph.D., Associate Professor, Center for Anatomy and Functional Morphology
Autonomic and tissue-specific gene regulation during development of the submandibular gland
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cellular Differentiation, DNA Recombination, Gene Regulation, Hormones, Neuromodulation, Receptors, Transcription Factors, Transgenic Mice
Larry J. Siever, M.D., Professor, Department of Psychiatry
1)Cognitive impairment and cognitive augmentation in the schizophrenia spectrum. 2)Serotonergic genetics and pharmacology and aggression in personality disorders.
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Behavior, Schizophrenia, Translation
Clinical Research Topic(s):
Patient-oriented research, Translational research
Jeremy M. Silverman, Ph.D., Professor, Department of Psychiatry
My group is especially focused on characterizing phenotypes and endophenotypes in schizophrenia, dementia, successful aging, and autism for use in molecular genetic studies.
Training Area(s):
Type(s) of Research:
Research Topic(s):
Aging, Alzheimer's Disease, Autism, Genetics, Memory, Schizophrenia
Clinical Research Topic(s):
Behavioral medicine, Epidemiologic research, Molecular epidemiology, Patient-oriented research
Viviana Simon, M.D., PH.D., Assistant Professor, Department of Medicine (Infectious Diseases)
HIV pathogenesis and host-virus interactions
Training Area(s):
Type(s) of Research:
Research Topic(s):
Lawrence Sirovich, Ph.D., Professor, Department of Pharmacology and Systems Therapeutics
Image analysis; Mathematical modeling of various biomedical problems, and in particular the mammalian visual system
Training Area(s):
Type(s) of Research:
Research Topic(s):
Computational Neuroscience, Image Analysis, Mathematical Modeling of Biomedical Systems
Mihaela Skobe, Ph.D., Assistant Professor, Department of Oncological Sciences
Cancer metastasis, lymphangiogenesis, angiogenesis
Training Area(s):
Type(s) of Research:
Research Topic(s):
Angiogenesis, Antigen Presentation, Cancer, Cell Adhesion, Chemokines, Chemotaxis, Endothelial Cells, Growth Factors and Receptors, Immunology, Lymphangiogenesis, Metastasis
Hans-Willem Snoeck, M.D., Ph.D., Associate Professor, Department of Gene and Cell Medicine
Stem cell biology; immunology; gene therapy; hematopoiesis
Training Area(s):
Research Topic(s):
Genetics, Genomics, Hematopoiesis, Lymphocytes, Stem Cells
Eric Sobie, Ph.D., Assistant Professor, Department of Pharmacology and Systems Therapeutics
Coupling of experiments and computational modeling to understand interactions between electrical and calcium signaling systems in ventricular myocytes
Training Area(s):
Type(s) of Research:
Research Topic(s):
Biophysics, Cardiovascular, Computational Biology, Electrophysiology, Mathematical Modeling of Biomedical Systems, Membrane Proteins/Channels, Signal Transduction
Sergei Y. Sokol, Ph.D., Professor, Department of Developmental and Regenerative Biology
Cell polarity in vertebrate development, neural development, axis specification, Wnt signaling, morphogenetic movements, asymmetric cell division.
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cell Motility, Developmental Neurobiology, Growth Factors and Receptors, Morphogenesis, Protein Trafficking & Sorting, Stem Cells
Philippe Soriano, Ph.D., Professor, Department of Developmental and Regenerative Biology
Growth factor signaling; Ephrin signaling and boundary formation; Gene trap mutagenesis
Training Area(s):
Type(s) of Research:
Research Topic(s):
Adipose, Cancer Genetics, Cell Biology, Developmental Biology, Embryology, Genetics, Growth Factors and Receptors, Human Genetics and Genetic Disorders, Knockout Mice, Oncogenes, Organogenesis, Protein Kinases, Stem Cells, Transgenic Mice, Vascular Development
David W. Sternberg, M.D., Ph.D., Assistant Professor, Department of Medicine (Hematology and Medical Oncology)
Aberrant protein tyrosine kinase signaling in cancer; translational control of gene expression in malignancy; mechanisms of resistance to protein tyrosine kinase inhibitors
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cancer, Drug Design and Discovery, Drug Resistance, Leukemia, Lymphoma, Oncogenes, Phosphorylation, Protein Kinases, Protein Translation, Proteomics
Frederick J. Suchy, M.D., Professor , Department of Pediatrics
Basolateral and canalicular transporters for bile acids and other organic anions
Training Area(s):
Type(s) of Research:
Research Topic(s):
Developmental Biology, Liver, Protein Trafficking & Sorting, Transporters
Herb B. (Hui Bin) Sun, Ph.D., Assistant Professor, Department of Orthopaedics
Gene regulation and signal transduction of joint tissue homeostasis; mechanotransduction pathway and its potential use for disease prevention and treatment; effects of chemo-factors and mechano-factors on MSC renewal, commitment, and differentiation; role of MSCs in wound healing and tissue engineering
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cartilage Biology, Cellular Differentiation, Gene Regulation, Inflammation, Osteoporosis, Signal Transduction, Skeletal Biology, Tendon Biology, Tendon Disease, Tissue Breakdown, Tissue Engineering, Wound Healing
Cheuk Y. Tang, Ph.D., Assistant Professor, Department of Radiology
Neurovascular Imaging Research and Molecular Imaging: the quest for biomarkers in diagnostic imaging
Training Area(s):
Type(s) of Research:
Research Topic(s):
Alzheimer's Disease, Axonal Growth and Degeneration, Brain Imaging, Computer Simulation, Demyelination, Diffusion Tensor Imaging, Image Analysis, Imaging, Positron Emission Tomography
Benjamin tenOever, Ph.D., Assistant Professor, Department of Microbiology
Host-pathogen interactions; virus-induced cell signaling
Training Area(s):
Type(s) of Research:
Research Topic(s):
Biodefense, Cellular Immunity, Chemokines, Chromatin, Cytokines, Immunology, Infectious Disease, Inflammation, Influenza Virus, Interferon, Interferon Antagonists, Macrophage, Mass Spectrometry, Microarray, Mitochondria, Molecular Biology, Paramyxovirus, Phosphorylation, Respiratory Tract, RNA, RNA Splicing & Processing, Signal Transduction, Transcription Factors, Transgenic Mice, Vaccine Development, Viruses and Virology
Adrian T. Ting, Ph.D., Assistant Professor, Department of Medicine
Antiviral immune response; signal transduction in cell survival and cell death; molecular mechanisms of inflammation
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Antigen Presentation, Apoptosis/Cell Death, Autoimmunity, Bioinformatics, Cellular Immunity, Immunology, Inflammation, Lymphocytes, Protein Kinases, Signal Transduction, T Cells, Viruses and Virology
Domenico Tortorella, Ph.D., Assistant Professor, Department of Microbiology
Viral subversion of the adaptive branch of the immune system
Training Area(s):
Type(s) of Research:
Research Topic(s):
Biodefense, Cell Biology, Cellular Immunity, Immunology, Infectious Disease, Membranes, Microarray, Protein Complexes, Protein Degradation, Protein Folding, Viruses and Virology
Edmund B. Trexler, Ph.D., Assistant Professor, Department of Ophthalmology
Retinal processing of visual signals and synaptic adaptation to changing stimuli
Training Area(s):
Type(s) of Research:
Research Topic(s):
Connexins, Electrophysiology, Gap Junctions, Glutamate (NMDA & AMPA) Receptors, Image Analysis, Membrane Proteins/Channels, Neural Networks, Neurophysiology, Neurotransmitters, Retina, Synapses, Synaptic Plasticity
Iban Ubarretxena, Ph.D., Assistant Professor, Department of Structural and Chemical Biology
Training Area(s):
Type(s) of Research:
Research Topic(s):
Martin J. Walsh, Ph.D., Associate Professor, Department of Pediatrics
Modulation of chromatin structure and function
Training Area(s):
Type(s) of Research:
Research Topic(s):
Apoptosis/Cell Death, Bioinformatics, Cancer, Cell Cycle, Cell Division, Cellular Differentiation, Chromatin, Developmental Biology, Drug Design and Discovery, Epigenetics, Gene Regulation, Human Genetics and Genetic Disorders, Mass Spectrometry, Mitosis, Nucleus, Oncogenes, Protein Structure/Function, Proteomics, RNA, Transcription Factors, Transcriptional Activation and Repression
Lu-Hai Wang, Ph.D., Professor, Department of Microbiology
Oncogenes; cell transformation and signal transduction of receptor tyrosine kinases; molecular basis for oncogenesis and targets for cancer therapy
Training Area(s):
Type(s) of Research:
Research Topic(s):
Cancer, Cell Transformation, Growth Factors and Receptors, IGF-1 Receptor, Insulin Receptor, Metastasis, Oncogenes, Protein Kinases, Signal Transduction, Tumorigenesis
Rong Wang, Ph.D., Associate Professor, Department of Genetics and Genomic Sciences
Proteomics and biological mass spectrometry
Training Area(s):
Type(s) of Research:
Research Topic(s):
Alzheimer's Disease, Biophysics, Mass Spectrometry, Neuro-degeneration/protection, Obesity, Phosphorylation, Post-Transcriptional Processing, Protein Complexes, Protein Degradation, Proteomics
Peter E. Warburton, Ph.D., Associate Professor, Department of Genetics and Genomic Sciences
Chromosome structure, centromeres, artificial chromosomes, epigenetics, gene therapy, repetitive DNA
Training Area(s):
Type(s) of Research:
Research Topic(s):
Adipose
Paul M. Wassarman, Ph.D., Professor , Department of Developmental and Regenerative Biology
Mechanisms of fertilization in mammals
Training Area(s):
Type(s) of Research:
Research Topic(s):
Developmental Biology, Protein Structure/Function, Proteomics, Reproductive Biology
Thomas Weber, Ph.D., Assistant Professor, Department of Gene and Cell Medicine
Adeno-associated virus biology and Gene Therapy
Training Area(s):
Type(s) of Research:
Research Topic(s):
Gene Therapy, Viruses and Virology
Klaudiusz R. Weiss, Ph.D., Professor, Department of Neuroscience
Cellular and molecular neurobiology of behavior
Training Area(s):
Type(s) of Research:
Research Topic(s):
Aplysia, Behavior, cAMP, Cognitive Neuroscience, Electrophysiology, GABA, Glutamate (NMDA & AMPA) Receptors, Hormones, Membrane Proteins/Channels, Memory, Motor Neuron, Neural Networks, Neuromodulation, Neuropeptides, Neurotransmitters, Phosphorylation, Protein Kinases, Protein Phosphatases, Receptors, Synapses
James G. Wetmur, Ph.D., Professor, Department of Microbiology
Molecular epidemiology; technology development for genomics and proteomics
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Bacterial Genetics, DNA Recombination, DNA Replication, Enzymology, Epigenetics, Folates, Gene Regulation, Gene Therapy, Genetics, Genomics, Immunology, Molecular Epidemiology, Molecular Motors, Protein Complexes, Protein Structure/Function, RNA, Spectroscopy, Thermodynamics, Transcription Factors, Viruses and Virology
Clinical Research Topic(s):
Molecular epidemiology
Jose M. Wolosin, Ph.D., Professor, Department of Ophthalmology
Training Area(s):
Research Topic(s):
Savio L. C. Woo, Ph.D., Professor, Department of Gene and Cell Medicine
Gene Therapy for Cancer and Inherited Diseases
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Clinical Research
Research Topic(s):
Anti-Tumor Therapy, Bacterial Genetics, Cancer, Chemotaxis, Cytokines, Gene Therapy, Human Genetics and Genetic Disorders, Inflammation, Interferon, Interferon Resistance, Liver, Stem Cells, Viruses and Virology
Clinical Research Topic(s):
Patient-oriented research, Translational research
Huabao Xiong, M.D., Ph.D., Assistant Professor, Department of Medicine
Training Area(s):
Type(s) of Research:
Research Topic(s):
Autoimmunity, Cancer, Cytokines, Signal Transduction
Pin-Xian Xu, Ph.D., Associate Professor, Department of Genetics and Genomic Sciences
Training Area(s):
Type(s) of Research:
Research Topic(s):
Shoshana Yakar, Ph.D., Assistant Professor, Department of Medicine
Serum IGF-I deficiency and its implication on skeletal integrity and tumor growth.
Training Area(s):
Type(s) of Research:
Research Topic(s):
Bone Biology, Bone Metabolism, Growth, Growth Factors and Receptors, Knockout Mice, Metastasis, Osteoporosis, Skeletal Biology, Transgenic Mice, Tumorigenesis
Sergei Yakushin, Ph.D., Assistant Professor, Department of Neurology
Vestibular control of eye movements and locomotion
Training Area(s):
Type(s) of Research:
Research Topic(s):
Behavior, Biophysics, Brain, Cerebellum, Computational Neuroscience, Eye Movements, Inner Ear, Locomotion, Mathematical Modeling of Biomedical Systems, Microgravity, Motor Control, Motor Neuron, Neural Code, Neural Networks, Neurobiology, Neuromuscular System, Neurophysiology, Neuroscience, Postural Control, Vestibular, Vision
Qin Yu, Ph.D., Assistant Professor , Department of Oncological Sciences
Effects of tumor microenvironment on tumor invasion/metastasis and tumor angiogenesis; Identification of targets and agents for therapeutic intervention of human glioma, ovarian cancer, melanoma, and breast cancer.
Training Area(s):
Type(s) of Research:
Research Topic(s):
Angiogenesis, Anti-Tumor Therapy, Apoptosis/Cell Death, Cell Adhesion, Cell Motility, Cytoskeleton, Endothelial Cells, Extracellular Matrix, Growth Factors and Receptors, Metastasis, Oncogenes, Signal Transduction, Tumor Suppressor Genes, Tumorigenesis
Zhenyu Yue, Ph.D., Assistant Professor, Department of Neurology
Molecular mechanisms of neurodegeneration; Molecular basis of Parkinson's Disease pathogenesis; Regulation of autophagy in neurons and its implication in axonal and neuronal degeneration.
Training Area(s):
Type(s) of Research:
Research Topic(s):
Aging, Apoptosis/Cell Death, Autophagy, Axonal Growth and Degeneration, Basal Ganglia, Brain, Cell Biology, Cerebellum, Gene Regulation, Genetics, Growth Cone, Human Genetics and Genetic Disorders, Imaging, Intracellular Transport, Knockout Mice, Lysosomes/endosome, Mass Spectrometry, Membrane Proteins/Channels, Microtubules, Mitochondria, Molecular Biology, Motor Neuron, Neuro-degeneration/protection, Oxidative Stress, Parkinson's Disease, Pathology, Protein Complexes, Protein Degradation, Protein Kinases, Protein Structure/Function, Protein Trafficking & Sorting, Proteomics, Signal Transduction, Synapses
Mone Zaidi, M.D., Ph.D., Professor, Department of Medicine
Cell and molecular biology and bone cells; intracellular calcium homeostasis
Training Area(s):
Type(s) of Research:
Research Topic(s):
Bone Biology, Bone Metabolism, Cell Biology, Cytokines, Developmental Biology, Gene Expressions, Genetics, Hormones, Immunosuppression, Macrophage, Microarray, Molecular Biology, Neuromodulation, Osteoporosis, Signal Transduction, Skeletal Biology, Thyroid, Transcription Factors
David Y. Zhang, M.D., Ph.D., Associate Professor, Department of Pathology
Molecular cancer biology with focus on signal transduction pathways and technology development for cancer diagnosis
Training Area(s):
Type(s) of Research:
- Clinical Research
- Translational Research
Research Topic(s):
Apoptosis/Cell Death, Cancer, Cell Cycle, Drug Design and Discovery, Molecular Biology, Nanotechnology, Pathology, Proteomics
Hongyan Zhou, M.D., Ph.D., Assistant Professor, Department of Neuroscience
Training Area(s):
Type(s) of Research:
Research Topic(s):
Ming-Ming Zhou, Ph.D., Professor and Chair, Department of Structural and Chemical Biology
Structural biology of receptor signaling, histone-directed chromatin biology and gene regulation; Mechanism-based disease biology and drug discovery; Protein NMR spectroscopy, biochemistry, molecular and chemical biology
Training Area(s):
Type(s) of Research:
Research Topic(s):
Aging, AIDS/HIV, Alzheimer's Disease, Anti-Tumor Therapy, Biophysics, Cancer, Cell Biology, Chromatin, Crystallography, Developmental Biology, Diabetes, DNA Repair, DNA Replication, Drug Design and Discovery, Enzymology, Epigenetics, Gene Regulation, Genomics, Immunology, Infectious Disease, Inflammation, Leukemia, Molecular Biology, Oncogenes, Parkinson's Disease, Protein Complexes, Protein Structure/Function, Proteomics, RNA, Spectroscopy, Stem Cells, Structural Biology, Thermodynamics, Transcription Factors, Transcriptional Activation and Repression, Viruses and Virology
Qiang Zhou, Ph.D., Assistant Professor, Department of Neurology
Synaptic and spine plasticity during neural development and degeneration
Training Area(s):
Type(s) of Research:
Research Topic(s):
Autism, Brain, Cytoskeleton, Developmental Neurobiology, Electrophysiology, Glutamate (NMDA & AMPA) Receptors, Hippocampus, Imaging, Memory, Neurobiology, Neurophysiology, Neuroscience, Parkinson's Disease, Synapses, Thalamus, Trafficking, Two-Photon Imaging
Karen S. Zier, Ph.D., Professor, Department of Medicine
Tumor immunology; T cells; immunotherapy, and immunosuppression
Training Area(s):
Type(s) of Research:
- Basic Science Research
- Translational Research
Research Topic(s):
Immunology, T Cells
Clinical Research Topic(s):
Translational research
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