Description: The goal of this course is to provide a broad-based systematic approach to the problem of virus-host interactions. The course is designed to be coordinated with the bi-annual New York Academy of Sciences Symposium on Virus-Host Interactions. All first year and second year students interested in cell biology, immunology, and/or molecular genetics/gene therapy are encouraged to participate.
This non-modular course will begin with an introduction to viral immunity and will then explore the strategies that viruses have developed in order to evade them. While all viruses enter cells, replicate their genomes, and then exit, the specific tactics which they have evolved to do this differ dramatically among the virus groups. Specifically, we will discuss (i) the basic life cycle of relevant viruses and (ii) the ways in which they interact with their host cells and evade immune detection.
Suggested textbooks: Students will be expected to expand their knowledge by reading and understanding the relevant chapters in the following texts. (i) Principles of Virology, Second Edition, edited by Jane Flint et al. (ASM Press, Washington, DC, 2003). (ii) Fields Virology, Fifth edition, Lippincott Williams and Wilkins, 530 Walnut St. Philadelphia, PA 2007 (iii) Viruses, by Arnold J. Levine (Scientific American Library, New York, 1992).
Evaluations: Two exams (non-cumulative)
Exam I. Part I. Introduction to viral immunity. 30%
Exam II. Part II. Viruses and their strategies to evade immune detection, 70%