Mount Sinai School Of Medicine
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Training Faculty 

Cellular & Molecular Neurobiology

Credits: 4
Course Number: BSR1702


Course Director: Cristina Alberini, Greg Phillips
E-Mail: Cristina.Alberini@mssm.edu , Greg.Phillips@mssm.edu

Course Description:

Cellular and Molecular Neurobiology covers the basic cellular and molecular principles of neuronal and glial cells. The lectures address protein synthesis, biochemistry, receptor activation and signalling, cytoskeleton and adhesion, physiological and morphological plasticity, development, and disease stressing those aspects that are unique to cells of the nervous system. G351 can also be offered in a modular format to those students who have already successfully completed Core II. There are three exams, one each at the end of the three major sections of the course, and a weekly journal club where students present and discuss key research articles.

PROTEIN SYNTHESIS,PROCESSING AND REGULATION

Nucleus
Transcription 1 (mRNA synthesis and RNA processing)
Transcription 2 (RNA transport and localization)
Transcription 3 (regulation of gene expression)
Translation 1 (protein synthesis and folding)
Translation 2 (post translational modification and processing)
Vesicle trafficking and endocytosis
Papers on Ubiquitination, Degradation
Translation 3 (local protein synthesis)

NEURONAL BIOCHEMISTRY
Neurotrophins: what are they, what do they do, where do they act?
Cellular Metabolism 1
Cellular Metabolism 2
Papers on Metabolism
Peptide synthesis, processing and release
Classical neurotransmitter biosynthesis, degradation, uptake

NEUROTRANSMITTER RECEPTORS
Receptor pharmacology 1
Receptor pharmacology 2
Papers on Neurotrophins
neurotransmitter receptors: G-protein coupled receptors
signal integration: metabotropic and ionotropic
Papers on integration

CYTOSKELETON and ADHESION
Actin Cytoskeleton 1
Actin cytoskeleton 2
Intermediate Filaments and MTs 1
Intermediate Filaments and MTs 2
Papers on Cytoskeleton
Intermediate Filaments and MTs 3
Adhesive Junctions and PSDs
Gap Junctions
papers on synapses
President's Day
Cell Polarity; localization within compartments
Blood Brain Barrier

PHSYIOLOGICAL AND MORPHOLOGICAL PLASTICITY
Cellular Plasticity (LTP and LTD)
Dendritic Spines

SIGNALING
Kinases
Phosphatases
Neural Induction/Pattern Formation
Papers on Signaling

DEVELOPMENT
Cytosplasm to Nucleus signaling
Neural Stem Cells
Neurogenesis and migration: cortex and cerebellum
Neuronal Differention
Neural Induction/Pattern Formation
Myelination
Synapse development
Papers on topographic maps
Programmed cell death
Cortical Arealization

CELL BIOLOGY OF DISEASE
Mechanisms of neuronal degeneration-I
Mechanisms of neuronal degeneration-II

MODEL ORGANISMS
c. elegans
Vertebrates models: Zebrafish, Xenopus
Mouse models (transgenic & knockout)
Papers on Degeneration


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