Systems Neuroscience is an introductory course designed to provide a rigorous survey of brain structure and function encompassing comparative and functional neuroanatomy, systems-level neuroscience and physiology, and neuropathology. The class is composed of lectures from the medical school's Brain and Behavior course and advanced graduate-level lectures that cover in greater depth the relevant subject (s) of that week. Periodically, students are given a journal article relevant to the topic of that week in which they will be expected to answer three questions in advance of a student-led discussion session. Grades will be determined by participation in the discussion and paper-presentation sessions and by four, short-answer, non-cumulative quizzes. Our goals and objectives are for you to gain fundamental understanding of systems-level neurobiology and neurophysiology while simultaneously gaining an appreciation for how basic neuroscience impacts our understanding of many clinically relevant aspects of human neuropathology. We feel this will best enable students to gain comprehensive knowledge of many aspects of human basic and clinical neuroscience, which is a cornerstone of translational issues relevant to research and programmatic directions supported by the Department of Neuroscience, Mount Sinai, and the National Institutes of Health.