Course Director: Terry Ann Krulwich
E-Mail: Terry.Krulwich@mssm.edu
Course Description: Time: Varies
Room: Annenberg 19-50
Start Date: 08/24/09
This active-learning course will introduce core biochemical, cell biological and molecular mechanisms together with basic bioinformatic and systems biology concepts and applications in the context of human biomedical research. The emphasis is 'top-down', beginning with a pathophysiological condition studied from a clinical perspective and moving towards explication of the molecular and metabolic logic, regulatory circuits and cell and tissue specific properties that distinguish the disease and normal state.
The goals of this course are to provide students with an appreciation of the complexity of biological systems across scales and to give insight into pathophysiology as a basis for scientific enquiry and development of new therapeutic strategies. Students will be guided to relevant textbook material and current reviews, and will also participate in analyses of primary journal articles to enhance
their study of scientific method and to illustrate a variety of experimental and computational approaches to contemporary translational biomedicine. Problem sets and the methodologies for handling large data sets, including epidemiological and genetic data, will be introduced.
This course is 6 credits with a journal club included in the body of five modules. The first module will be Introduction to Systems Biomedicine and will include an introduction to modeling using Matlab. The subsequent modules will focus on Diabetes, Cancer, Renal Disease and Drug Abuse.
|
