The purpose of this course is to familiarize students with basic principles of probability and statistics as applied to biomedical research. No prior knowledge of statistics is required. Our goal is to prepare students for critical reading of the scientific literature and for applying basic statistical methods to their own research. The course will be taught using SPSS; the fundamentals of SPSS will be presented. Topics covered include laws of probability, probability distributions and density functions (binomial, normal), the central limit theorem, confidence intervals, hypothesis testing, statistical power and sample size estimation, t-tests, nonparametric methods, chi-square tests, simple linear regression and correlation, one-way analysis of variance, two-way analysis of variance, principles of experimental design, completely randomized design, randomized block design, and factorial treatment designs.